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Robert Zimmermann

Robert Zimmermann is a molecular biologist and Associate Professor at the Institute of Molecular Biosciences of the University of Graz.

Research interests:

His focus is on the biological characterization of enzymes catalyzing the degradation of lipids in mammalian cells, e.g. monoacylglycerol lipase (MGL) and ABHD6. These lipolytic enzymes, designated as lipases, play key roles in many biological and pathological processes because they control the availability of lipids for cellular energy production, synthetic reactions, and signaling events. A large number of genetic diseases have been identified which exhibit deficiencies in phospholipid, triacylglycerol, or cholesterylester catabolism. Moreover, changes in lipolytic activities have been associated with common metabolic disorders, such as obesity, dyslipidemia, and type-2 diabetes. Nevertheless, many lipases are poorly characterized or remain to be discovered. The aim of his research is to identify novel lipases and to explain their function with the help of biochemical, cell biological and molecular biological methods.

Coordinates:

  • Institute of Molecular Biosciences
    University of Graz
    Heinrichstraße 31/2
    8010 Graz, Austria
  • Tel: +43 316 380-1914
    Fax: +43 316 380-9016
    e-mail
  • CV: link
  • Publications: link

Lab infrastructure:

  • HPLC-FD, qTOF-MS, EVOQ Triple Quad-MS for neutral and phospholipid analyses
  • Cell culture laboratory
  • Radionuclide laboratory
  • Biochemical, molecular biology and cell biology facilities
  • Animal facility with global and tissue-specific knockout mouse models

Illustrations: