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Christian Wadsack
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Christian Wadsack is a biochemist by training and Associate Professor at the
Department of Gynecology and Obstetrics
of the Medical University of Graz.
Research interests:
The laboratory is conducting research on the molecular mechanisms underlying pregnancy pathologies.
A longstanding interest has been on the role of lipid and lipoprotein transfer across the human
placenta. In particular, his research is focused on lipids that impact inflammatory pathways at the
placental-fetal endothelium in pregnancy-associated diseases, such as gestational diabetes or
pre-eclampsia. Metabolic imbalances and environmental stimuli, like cytokines, eicosanoids or lipids
are known to trigger endothelial cell function. The laboratory uses the dual ex vivo placenta
perfusion system and in vitro culture assays of primary placental trophoblasts, endothelial
cells and macrophages as models to study the function of the human placenta.
Coordinates:
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Department of Gynecology and Obstetrics
Perinatal Research Laboratory
Medical University of Graz
Auenbruggerplatz 14
8036 Graz, Austria
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Tel: +43 316 385-81074
Fax: +43 316 385-12506
e-mail
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CV: link
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Publications: link
Lab infrastructure:
- Ex vivo dually placental perfusion approach
- Cell culture facilities for isolation of primary human placental cells
- Primary placental arterial and venous, macrophages, and trophoblasts as cell models
- Ultracentrifugation and facility for isolation and characterization of maternal and neonatal lipoproteins
- Assays for HDL functionality
- Biochemical, molecular biology and cell biology facilities
Illustrations:
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Scheme of the ex vivo placental perfusion system.
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